Laser diffraction method11/9/2023 Particles illuminated in a collimated laser-beam scatter light over a range of angles. Laser diffraction is an ensemble particle-sizing technique, which means it provides a result for the whole sample, rather than building up distributions from data for individual particles, in the way that, for example, image analysis or microscopy does. Understanding the basic principles of laser diffraction is essential for successful method development. There is a wealth of information to support method development, the success of which depends on a rigorous and systematic examination of the factors known to influence results. This process is given considerable emphasis in the International Organization for Standardization's (ISO) 13320:2009 standard for laser diffraction released at the end of 2009, reflecting that understanding of this technique among industry has grown significantly during the past decade (1). However, streamlining measurement to this degree demands the development of a robust secure method that will consistently deliver reliable and reproducible data. As a result, for many routine users, particle-size measurement is now simply a matter of loading the sample and pressing a button. Fast, nondestructive and suitable for a broad size range (0.1 to 3000 μm), laser diffraction lends itself to full automation. ![]() During recent decades, the unique attributes of laser-diffraction analysis have positioned it as the particle-sizing technique of choice for the resulting spectrum of pharmaceutical applications. Particle size is a critical quality attribute for a diverse array of pharmaceutical products, from topical ointments to powders for pulmonary delivery.
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